Benzoyl chloride, 3,4-dichloro- → tert-Butyl 2-[4-(3,4-dichlorobenzoyl)-1-piperazinyl]ethylcarbamate

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Reaction Steps

The product from step (i) above (3 g) was dissolved in pyridine (12 ml), 3,4-dichlorobenzoyl chloride (2.05 g) was added and the mixture stirred at room temperature for 18 hours. A solid was collected by filtration and purified by chromatography (dichloromethane:methanol: 0.880 NH4OH, 90:9:1) to give the sub-titled product as an oil (3.59 g).

Provenance & Evidence