化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyldimethylsilyl chloride → 1-O-benzyl-3-O-t-butyldimethylsilylglycerol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 反応物 | 3-(Benzyloxy)-1,2-propanediol | HCID 98072 | — |
| 反応物 | 1-o-Oleoyl-2-o-methyl-rac-glycerol | HCID 9947582 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-O-benzyl-3-O-t-butyldimethylsilylglycerol | HCID 15621787 | 100% |
反応手順
1-O-Oleoyl-2-O-methyl-rac-glycerol (Compound 44) To a mixture of 1-O-benzyl-glycerol (27 mL, 0.16 mol) and t-butyldimethylsilyl chloride (25 g, 0.17 mol) in dry CH2Cl2 (250 mL) under N2 was added DMAP (0.8 g, 6.6 mmol) followed by the addition of TEA (23 mL, 0.17 mol). After 3 hours, the mixture was washed with H2O (2×100 mL), dried (MgSO4) and concentrated to give 1-O-benzyl-3-O-t-butyldimethylsilyl-rac-glycerol (40) (48.8 g, 100%) as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949529B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-a32c6aa5f7274fb5a1c2d219d444d7fe |
| 出典メモ | uspto-grants-2005_09 |