HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Oxazole-3-carbonyl chloride → Isoxazol-3-carboxylic acid (4-oxo-3,4-dihydrophthalazin-1-ylmethyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Oxazole-3-carbonyl chloride | HCID 11007940 | — |
| Reactant | 4-(Aminomethyl)-1,2-dihydrophthalazin-1-one hydrochloride | HCID 16819633 | — |
| Product | Isoxazol-3-carboxylic acid (4-oxo-3,4-dihydrophthalazin-1-ylmethyl)amide | HCID 86593723 | — |
Reaction Steps
The title compound was prepared from 4-aminomethyl-2H-phthalazine-1-one hydrochloride (Geterotsikl, Soedin, 1972, (9), 15) and isoxazol-3-carbonyl chloride using the procedure described in Example 1, Part a. 1H NMR (360 MHz, d6-DMSO) δ 4.80 (d, J=6 Hz, 2H), 6.93 (s, 1H), 7.87 (t, J=7 Hz, 1H), 7.95 (t, J=7 Hz, 1H), 8.1 (d, J=7 Hz, 1H), 8.28 (dd, J=2 Hz, 7 Hz, 1H), 9.08 (s, 1H), 9.09 (t, J=2 Hz, 1H), 12.62 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949549B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-72f24dc209014a3d986bec061074a7b3 |
| Source note | uspto-grants-2005_09 |