Ethanol → HCID 22318053, compound

Participants

Reaction Steps

An ethanol solution of ethyl [(4-fluorobenzoyl)-(4-fluorophenyl)amino]acetate was mixed with 3 M sodium hydroxide aqueous solution and heated under reflux. The reaction solution was concentrated, the residue was mixed with 1 M hydrochloric acid and chloroform, the organic layer was separated, washed and dried and then the solvent was evaporated under a reduced pressure. A dichloromethane solution of the thus obtained carboxylic acid crude product was mixed with 4-aminoacetophenone and WSC.HCl in that order and then stirred. The reaction solution was mixed with 1 M hydrochloric acid, the organic layer was separated, washed and dried and then the solvent was evaporated under a reduced pressure. By purifying the thus obtained crude product by SCG, N-[(4-acetyl-phenylcarbamoyl)methyl]-4-fluoro-N-(4-fluorophenyl)benzamide (white foam) was obtained.

Provenance & Evidence