Sodium Hydroxide → HCID 86591174, compound

HRID 497061Notes

Reaction equation

HRID 497061 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]([CH2:16][N:17]([C:27]3[CH:39]=[CH:38][C:30]([O:31][CH2:32][C:33]([O:35]CC)=[O:34])=[CH:29][CH:28]=3)[C:18](=[O:26])[C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[O:15])=[CH:9][CH:8]=2)[N:6]=1.[OH-].[Na+:41]>C(O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][C:14]([CH2:16][N:17]([C:27]3[CH:28]=[CH:29][C:30]([O:31][CH2:32][C:33]([O-:35])=[O:34])=[CH:38][CH:39]=3)[C:18](=[O:26])[C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)=[O:15])=[CH:11][CH:12]=2)[N:6]=1.[Na+:41]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86591175HCID 86591175, compound

Product 1

HCID 86591174HCID 86591174, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (30 ml) solution of ethyl {4-[N-({[4-(2-aminothiazol-4-yl)phenyl]carbamoyl}methyl)-N-(4-fluorobenzoyl)amino]phenoxy}acetate (1.3 g) was mixed with 1 M sodium hydroxide aqueous solution (2.4 ml) and then stirred at room temperature overnight. After concentration of the reaction solution, the thus obtained crude product was recrystallized from ethanol to obtain 680 mg of sodium (4-[N-({[4-(2-aminothiazol-4-yl)phenyl]carbamoyl}methyl)-N-(4-fluorobenzoyl)amino]phenoxy)acetate (white crystals).

Workup

  1. customAfter concentration of the reaction solution, the thus obtained crude product
  2. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-495800e864864196a60bcd0d7e3f0f81
Source dataset
uspto-grants-2005_09
Patent number
US06949543B2

Reaction notes

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