Sodium Hydroxide → HCID 23692658, compound

Participants

Reaction Steps

Methanol (20 ml) solution of methyl N-({[4-(2-aminothiazol-4-yl)phenyl]carbamoyl}methyl)-N-(4-methoxyphenyl)terephthalamate monohydrochloride (800 mg) was mixed with 1 M sodium hydroxide aqueous solution (1.5 ml) and then heated under reflux for 4 hours. The reaction solution was concentrated, and ethanol (20 ml) and diisopropyl ether (10 ml) were added to the thus obtained residue to effect precipitation of crystals. After filtration, the crystals were washed with diisopropyl ether to obtain 530 mg of sodium N-({[4-(2-aminothiazol-4-yl)phenyl]carbamoyl}methyl)-N-(4-methoxyphenyl)terephthalamate (white crystals).

Provenance & Evidence