Lithium Hydroxide → HCID 18188087, compound

Participants

Reaction Steps

A solution of t-butyl 3-acetoxy-5-methyl-4-nitrophenylacetate (0.5 g, Reference Example 12) in methanol (6 mL) was treated with lithium hydroxide (0.2 g) in water (1.5 mL). After stirring for 2 hours the mixture was carefully acidified to pH 5 and then treated with ethyl acetate and sodium chloride. The organic layer was evaporated and the residue was dissolved in dichloromethane. This solution was dried and then evaporated to give the title compound (0.45 g) as a yellow green oil.

Provenance & Evidence