反应详情

A solution of (RS) 3-(6-amino-pyrid-3-yl)-butanoic acid hydrochloride (12.0 g, Reference Example 20) in methanol (300 mL) was treated with concentrated sulphuric acid (3.0 mL) then heated at reflux temperature for 8 hours. The reaction mixture was concentrated, then basefied with 5% aqueous sodium bicarbonate and then extracted with ethyl acetate . The extracts were washed with water, then with brine, then dried over magnesium sulphate and then evaporated to give the title compound (7.6 g) as a yellow oil.

1. temperaturethen heated
2. temperatureat reflux temperature for 8 hours
3. concentrationThe reaction mixture was concentrated
4. extractionextracted with ethyl acetate
5. washThe extracts were washed with water
6. dry with materialwith brine, then dried over magnesium sulphate
7. customevaporated