反应详情

Acetic anhydride (27.4 mL) was added to a stirred suspension of 2-amino-5-bromopyridine (10.0 g) in acetic acid (40 mL). The mixture was heated at reflux for 4 hours, then cooled to room temperature and then poured into water (200 mL). The resulting solid was collected, washed three times with water (300 ml) and then dried in vacuo at 70° C., affording the title compound as a white solid (10.9 g).

1. temperatureThe mixture was heated
2. temperatureat reflux for 4 hours
3. customThe resulting solid was collected
4. washwashed three times with water (300 ml)
5. customdried in vacuo at 70° C.