Bromine → HCID 22316759, compound

HRID 497232Notes

Reaction equation

HRID 497232 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([Cl:11])[CH:3]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[Cl:11])=[O:10]

Participants

4

Reactant 2

HCID 24408BromineHCID 155609501-(4-Bromo-2-chlorophenyl)ethan-1-one

Product 1

HCID 22316759HCID 22316759, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of 1-(4-bromo-2-chlorophenyl)-1-ethanone (11.58 g, 50 mmol) in dioxane (12 ml) was added a solution of bromine (8.12 g, 51 mmol) in dioxane (46 ml), and the mixture was stirred for 3 hours. Then the volatile was evaporated in vacuo. The residue was used for next reaction without purification. (15.6 g, 99% yield).

Workup

  1. customThen the volatile was evaporated in vacuo
  2. customThe residue was used for next reaction without purification

Sources & evidence

ORD record
ord-8e3d2a2b77494ef0bedb7b3b25018536
Source dataset
uspto-grants-2005_09
Patent number
US06949536B2

Reaction notes

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