Water → HCID 22316620, compound

Participants

Reaction Steps

A mixture of 5-(4-bromophenyl)-1-[3-fluoro-4-(methylsulfonyl)phenyl]-4-nitro-1H-pyrazole from step 2 (2.5 g, 5.7 mmol), iron powder (1.6 g, 28.4 mmol) and NH4Cl (30 mg, 0.57 mmol) in EtOH:H2O (40 mL: 10 mL) was refluxed for 1 h. After cooled to room temperature, the mixture was filtered by celite and washed with ethyl acetate and the filtrate was concentrated. Water (50 mL) was added to the residual oil and extracted with ethyl acetate (80 mL), dried over MgSO4, and concentrated in vacuo gave the title-compound (1.9 g, 82%).

Provenance & Evidence