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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 497284Generated: October 27, 2026

4-(Tributylstannyl)-2-(trimethylsilyl)thiazole → 2-Fluoro-4-[4-methyl-2-[4-(2-trimethylsilylthiazol-4-yl)phenyl)-1H-imidazol-1-yl]benzenesulfonamide

https://huagongshe.com/reaction/497284

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Tributylstannyl)-2-(trimethylsilyl)thiazoleHCID 22316680—
Reactant4-[2-(4-bromophenyl)-4-hydroxy-4-methyl-1H-imidazol-1-yl]-2-fluorobenzenesulfonamideHCID 22316746—
Product2-Fluoro-4-[4-methyl-2-[4-(2-trimethylsilylthiazol-4-yl)phenyl)-1H-imidazol-1-yl]benzenesulfonamideHCID 22317000—

Reaction Steps

The title compound was prepared according to the procedure of Example 153 (step 4) using 4-[2-(4-bromophenyl)-4-hydroxy-4-methyl-1H-imidazol-1-yl]-2-fluorobenzenesulfonamide instead of 2-(4-bromophenyl)-1-[3-fluoro-4-(methylsulfonyl)phenyl]-4-trifluoromethyl-1H-imidazole and using 4-(tributylstannyl)-2-trimethylsilylthiazole instead of 4-(tributylstannyl)thiazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06949536B2
Source datasetuspto-grants-2005_09
ORD IDord-1db567286eb743df9e0948d9adf55622
Source noteuspto-grants-2005_09