Water → HCID 135848013, compound

HRID 497286Notes

Reaction equation

HRID 497286 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:15]([F:23])[CH:14]=3)[N:11]=[C:10]([C:24]([F:27])([F:26])[F:25])[CH:9]=2)[CH:5]=[CH:4][C:3]=1[OH:28].S(Cl)([Cl:32])(=O)=O.O>C(Cl)Cl>[Cl:32][C:4]1[CH:5]=[C:6]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:15]([F:23])[CH:14]=3)[N:11]=[C:10]([C:24]([F:25])([F:26])[F:27])[CH:9]=2)[CH:7]=[C:2]([CH3:1])[C:3]=1[OH:28]

Participants

5

Reactant 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 135848014HCID 135848014, compound

Product 1

HCID 135848013HCID 135848013, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 2-methyl-4-[1-[3-fluoro-4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenol (0.332 g, 0.8 mmol) in CH2Cl2 (10 ml) was added sulfuryl chloride (0.113 g, 0.84 mmol) at room temperature, and the mixture was stirred for 30 minutes. The reaction mixture was poured into water, and the whole was extracted with CH2Cl2. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was recrystallized with CH2Cl2-hexane to give the subtitle compound (0.318 g, 88.6% yield).

Workup

  1. extractionthe whole was extracted with CH2Cl2
  2. washThe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe residue was recrystallized with CH2Cl2-hexane

Sources & evidence

ORD record
ord-4d9b5f9898a048b4bcecfb5d90552797
Source dataset
uspto-grants-2005_09
Patent number
US06949536B2

Reaction notes

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