N-benzyl-4-nitrobenzenesulfonamide → Benzylsulfamide

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Reaction Steps

N-benzyl-4-nitrobenzenesulfonamid (60 g, 1 eq) was dissolved in anhydrous ethanol (2 l) and Pd/C (10 g, 1 eq) was added under inert atmosphere. The mixture was stirred under a hydrogen atmosphere for 8 h. Then the solution was filtered over Celite, concentrated in vacuo to ˜40 ml and then crystallized. The product was washed twice with ethanol (20 ml) at 4° C., filtered and dried in vacuo to give 4-amino-N-benzylbenzenesulfonamide. Yield 75%.

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