反应详情

4-[3-(3-Cyanophenyl)-ureido]-N-(2,3,6-trifluorobenzyl)-benzenesulfonamide (230 mg, 0.5 mmol) was dissolved in HCl/MeOH (25 ml, 7 M) at 0° C. under inert atmosphere and stirred overnight at rt. The solution was concentrated and dried in vacuo to yield 99% of 3-{3-[4-(2,3,6-trifluorobenzyl-sulfamoyl)-phenyl]-ureido}-benzimidic acid methyl ester.

1. concentrationThe solution was concentrated
2. customdried in vacuo