Hydrochloride methanol → 3-{3-[4-(2,3,6-Trifluorobenzylsulfamoyl)-phenyl]-ureido}-benzimidic acid methyl ester

HRID 497316Notes

Reaction equation

HRID 497316 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:32])[NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][C:23]3[C:28]([F:29])=[CH:27][CH:26]=[C:25]([F:30])[C:24]=3[F:31])(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].Cl.[CH3:34][OH:35]>>[CH3:34][O:35][C:1](=[NH:2])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][C:10]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18](=[O:19])(=[O:20])[NH:21][CH2:22][C:23]3[C:28]([F:29])=[CH:27][CH:26]=[C:25]([F:30])[C:24]=3[F:31])=[CH:14][CH:13]=2)=[O:32])[CH:4]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 223189094-(3-(3-cyanophenyl)ureido)-N-(2,3,6-trifluorobenzyl)benzenesulfonamide

Product 1

HCID 697315573-{3-[4-(2,3,6-Trifluorobenzylsulfamoyl)-phenyl]-ureido}-benzimidic acid methyl esterYield 99%

Procedure

4-[3-(3-Cyanophenyl)-ureido]-N-(2,3,6-trifluorobenzyl)-benzenesulfonamide (230 mg, 0.5 mmol) was dissolved in HCl/MeOH (25 ml, 7 M) at 0° C. under inert atmosphere and stirred overnight at rt. The solution was concentrated and dried in vacuo to yield 99% of 3-{3-[4-(2,3,6-trifluorobenzyl-sulfamoyl)-phenyl]-ureido}-benzimidic acid methyl ester.

Workup

  1. concentrationThe solution was concentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-ff9abcb89eb64fcba7c64d61c31847db
Source dataset
uspto-grants-2005_09
Patent number
US06949567B2

Reaction notes

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