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In 6.0 ml of chloroform was dissolved 0.69 g of 4-methoxyphenacyl bromide, and 3.0 ml of N-ethyldiisopropylamine and 1.20 g of 1-(4-naphthalen-1-yl-butyl)piperazine dihydrochloride were added, followed by reflux with heating for an hour. The reaction solution was cooled to room temperature, and concentrated under reduced pressure. To the residue was added a saturated aqueous sodium bicarbonate solution and, after extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate. After removal of the drying agent by filtration, the filtrate was concentrated under reduced pressure to give a crude 1-[2-(4-methoxyphenyl)-2-oxoethyl]-4-(4-naphthalen-1-yl-butyl)piperazine.

1. additionwere added
2. temperatureby reflux
3. temperaturewith heating for an hour
4. concentrationconcentrated under reduced pressure
5. additionTo the residue was added a saturated aqueous sodium bicarbonate solution
6. extractionafter extraction with ethyl acetate
7. dry with materialthe organic layer was dried over anhydrous sodium sulfate
8. customAfter removal of the drying agent
9. filtrationby filtration
10. concentrationthe filtrate was concentrated under reduced pressure