Hydrogen chloride-ethyl acetate → HCID 69767282, compound

HRID 497335Notes

Reaction equation

HRID 497335 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]([N:34]2[CH2:39][CH2:38][N:37]([CH:40]([CH3:42])[CH3:41])[CH2:36][CH2:35]2)[CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=[CH:24][C:23]=3[O:32][CH3:33])[CH2:14][CH2:13]2)[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2].[ClH:43].C(OCC)(=O)C>CO>[ClH:43].[ClH:43].[ClH:43].[ClH:43].[C:1]([C:4]1[CH:5]=[C:6]([CH:10]([N:34]2[CH2:35][CH2:36][N:37]([CH:40]([CH3:42])[CH3:41])[CH2:38][CH2:39]2)[CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=[CH:24][C:23]=3[O:32][CH3:33])[CH2:14][CH2:13]2)[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22318654HCID 22318654, compound

Product 1

HCID 69767282HCID 69767282, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

74 mg of 1-[2-(3-Carbamoylphenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine was dissolved in 4 ml of methanol, and 1 ml of 4M hydrogen chloride/ethyl acetate solution was added. The solution was concentrated under reduced pressure, and the resulting solid was washed with ethyl acetate to give 70 mg of 1-[2-(3-carbamoylphenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine tetrahydrochoride.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. washthe resulting solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-2f6414b339d04ce7999b06426c9ffb2c
Source dataset
uspto-grants-2005_09
Patent number
US06949552B2

Reaction notes

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