4-{1-(4-Fluorophenyl)-2-[4-(naphthalen-1-yl-butyl)piperazin-1-yl]ethyl}-1-methylpiperidin-4-ol → (1-(4-Fluorophenyl)-2-[4-(naphthalen-1-yl-butyl)piperazin-1-yl]ethyl}-1-methylpiperidin-4-ol trihydrochloride

HRID 497344Notes

Reaction equation

HRID 497344 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C2(O)CCN(C)CC2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][CH:21]=3)[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[ClH:38].C([O:42][CH2:43][CH3:44])(=O)C>CO>[ClH:38].[ClH:38].[ClH:38].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:11]2[CH2:44][CH:43]([OH:42])[CH2:8][CH2:9][N:10]2[CH3:15])[CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][CH:21]=3)[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 178506544-{1-(4-Fluorophenyl)-2-[4-(naphthalen-1-yl-butyl)piperazin-1-yl]ethyl}-1-methylpiperidin-4-olHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 86589745(1-(4-Fluorophenyl)-2-[4-(naphthalen-1-yl-butyl)piperazin-1-yl]ethyl}-1-methylpiperidin-4-ol trihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

33 mg of 4-{1-(4-Fluorophenyl)-2-[4-(naphthalen-1-yl-butyl)piperazin-1-yl]ethyl}-1-methylpiperidin-4-ol was dissolved in 4 ml of methanol, and 1 ml of 4M hydrogen chloride/ethyl acetate solution was added. The solution was concentrated under reduced pressure, and the resulting solid was washed with ethyl acetate to give 35 mg of 4-{(1-(4-fluorophenyl)-2-[4-(naphthalen-1-yl-butyl)piperazin-1-yl]ethyl}-1-methylpiperidin-4-ol trihydrochloride.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. washthe resulting solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-d5eab148f7e04de2b154021fbed9e86a
Source dataset
uspto-grants-2005_09
Patent number
US06949552B2

Reaction notes

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