Hydrogen chloride-ethyl acetate → 1-[2-(4-Fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]-piperazine trihydrochloride

HRID 497350Notes

Reaction equation

HRID 497350 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:32]2[CH2:37][CH2:36][N:35]([CH:38]([CH3:40])[CH3:39])[CH2:34][CH2:33]2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][C:21]=3[O:30][CH3:31])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[ClH:41].C(OCC)(=O)C>CO>[ClH:41].[ClH:41].[ClH:41].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH:32]2[CH2:33][CH2:34][N:35]([CH:38]([CH3:40])[CH3:39])[CH2:36][CH2:37]2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][C:21]=3[O:30][CH3:31])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 223186351-[2-(4-Fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine

Product 1

HCID 223186341-[2-(4-Fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]-piperazine trihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.11 g of 1-[2-(4-Fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-[4-(2-methoxy-naphthalen-1-yl)butyl]piperazine was dissolved in 4 ml of methanol, and 1 ml of 4M hydrogen chloride/ethyl acetate solution was added. The solution was concentrated under reduced pressure, and the resulting solid was washed with ethyl acetate to give 0.12 g of 1-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]-piperazine trihydrochloride.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. washthe resulting solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-029ec2ab38ff439da1af3cc788a25306
Source dataset
uspto-grants-2005_09
Patent number
US06949552B2

Reaction notes

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