反应详情

1-[2-(4-Fluorophenyl)-2-(4-methylpiperazino)ethyl]-4-[4-naphthalen-1-yl-butyl]piperazine hydrochloride obtained in Example 2 (6) was resolved by means of HPLC (Chiralpak AD (manufactured by Daicel Co.), 2φ×25 cm, mobile phase: hexane-isopropanol-diethylamine=95:5:0.1, flow rate 5.0 ml/min). After the resolution, the solvent was concentrated under reduced pressure, dissolved in ethanol, and introduced to the hydrochloride by 4M hydrogen chloride/ethyl acetate solution, and the solvent was concentrated under reduced pressure to give 1-[2-(4-fluorophenyl)-2-(4-methylpiperazino)ethyl]-4-[4-naphthalen-1-yl-butyl]piperazine hydrochloride (optically active compound).

1. concentrationAfter the resolution, the solvent was concentrated under reduced pressure
2. dissolutiondissolved in ethanol
3. additionintroduced to the hydrochloride by 4M hydrogen chloride/ethyl acetate solution
4. concentrationthe solvent was concentrated under reduced pressure