Dimethylformamide → HCID 10311699, compound

Participants

Reaction Steps

A small reaction vessel was charged with the compound of from Part A (0.053 g, 0.20 mmol), 2-(4-Methoxyphenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (0.037 g, 0.13 mmol), 4-methylmorpholine (36 ul, 0.33 mmol) and DMF (3 mL). While stirring under N2, Castro's Reagent (0.089 g, 0.20 mmol) was added and the reaction mixture was allowed to stir at room temperature for 48 h. The reaction was concentrated and purified by prep LC/MS to obtain the target compound. (0.016 g, 23% yield). 1HNMR (DMSO-d6) δ 8.72 (d, 1H), 7.50-7.41 (m, 7H), 7.34-7.23 (t, 1H), 7.08-7.03 (d, 2H), 4.49-4.45 (m, 2H), 3.81 (s, 3H), 3.77 (m, 2H), 3.14 (m, 2H), 2.98 (m, 2H), 2.80 (bs, 4H), 1.89 (m, 2H), 1.71 (m, 2H); MS (ESI+) m/z 532.5, (M+H)+.

Provenance & Evidence