HCID 22319317, compound → HCID 10161478, compound

Participants

Reaction Steps

The methyl benzoate (0.130 g) was taken up in 20 mL 1:1 THF/MeOH and was treated with 1 M LIOH (3 mL). The mixture was stirred at room temperature for 48 hours. The mixture was then concentrated, and the residual oil was purified by chromatography (MPLC, silica, gradient 95:5 to 75:25 (CH2Cl2/MeOH). Fractions containing the desired product were combined, concentrated, and dried in vacuo overnight to give 2-[2-(3,4-dichlorobenzylamino)-indan-5-ylamino]-5-methoxy-benzoic acid (0.03 g, 24% yield). MS (APCI) m/z 457.0 (M++1). CHN for (C24H22Cl2N2O3·0.6H2O) calc: C, 61.57, H, 4.98, N, 5.98; found: C, 61.23, H, 4.88, N, 5.69.

Provenance & Evidence