Sodium Hydroxide → HCID 10161541, compound

HRID 497442Notes

Reaction equation

HRID 497442 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([NH:19][C:20]2[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:21]=2[C:22]([O:24]C)=[O:23])[CH2:13]3)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>C1COCC1.CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([NH:19][C:20]2[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:21]=2[C:22]([OH:24])=[O:23])[CH2:13]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10140170HCID 10140170, compound

Product 1

HCID 10161541HCID 10161541, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

By following the procedure of Example 4, methyl 2-[5-(3,4-dichlorophenylamino)-indan-2-ylamino]-5-nitro-benzoate was reacted with sodium hydroxide in THF/MeOH to give 2-[5-(3,4-dichlorophenylamino)-indan-2-ylamino]-5-nitro-benzoic acid (0.017 g, 18% yield). MS (APCI) m/z 457.9 (M++1).

Sources & evidence

ORD record
ord-e15641e8610c4568afbab41783932071
Source dataset
uspto-grants-2005_09
Patent number
US06949575B2

Reaction notes

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