Hydrochloric Acid → (2R)-2-Chloro-3-(1H-imidazol-5-yl)propanoic acid

Participants

Reaction Conditions

Reaction Steps

A cold solution of sodium nitrite (2.63 g, 38 mmol) in water (5 ml) was added dropwise to a stirred suspension of D-histidine (2 g, 11.5 mmol) in concentrated hydrochloric acid (30 ml) at −5° C. The mixture was stirred at 0° C. for 1 hour and then at room temperature for 17 hours. The mixture was cooled and basified with aqueous ammonium hydroxide solution (2N) until pH=4-5. The solvent was then removed by evaporation under reduced pressure to afford (2R)-2-chloro-3-(1H-imidazol-4-yl)propanoic acid.

Provenance & Evidence