Sodium Iodide → HCID 22319709, compound

Participants

Reaction Steps

4.5 g (0.0095 mol) of isopropyl 2-butyl-3-[4-(3-bromopropyl)benzoyl]-1-benzofuran-7-carboxylate are dissolved in 80 ml of acetonitrile. 3.68 g (0.0285 mol) of dibutylamine are then added, followed by 1.42 g (0.0095 mol) of sodium iodide and 3.94 g (0.0285 mol) of potassium carbonate. The mixture is brought to reflux for 15 hours and is then evaporated. Extraction is carried out with diethyl ether and the extract is washed with water and a sodium chloride solution. Purification is subsequently carried out by chromatography on silica (eluent: 100/3/0.2 dichloromethane/methanol/aqueous ammonia), which gives 2.91 g of the desired compound in the free base form (yield: 57%).

Provenance & Evidence