反应详情

An epoxide mixture (3.5 g), 17β-hydroxy-4,5-epoxy-14α,15α-methylene-androstan-3-one, (step 1) is dissolved in 50 mL of acetic acid, which contains 2% by volume of concentrated sulfuric acid. The solution is allowed to stand for 3 days at 10° C. After that, it is treated with 200 mL ethyl acetate and neutralized with sodium carbonate solution. The organic phase is dried and concentrated. The residue is dissolved in 100 mL of methanol, treated with 4 g of potassium hydroxide, refluxed for 1 hour and then cooled. After neutralization with 50% acetic acid, it is poured into 1 L of water and the crystals are filtered off with suction, 4,17β-Dihydroxy-14α,15α-methylene-androst-4-ene-3-one being obtained.

1. customThe organic phase is dried
2. concentrationconcentrated
3. dissolutionThe residue is dissolved in 100 mL of methanol
4. additiontreated with 4 g of potassium hydroxide
5. temperaturerefluxed for 1 hour
6. temperaturecooled
7. additionAfter neutralization with 50% acetic acid, it is poured into 1 L of water
8. filtrationthe crystals are filtered off with suction, 4,17β-Dihydroxy-14α,15α-methylene-androst-4-ene-3-one being
9. customobtained