Piperidine → HCID 67042716, compound

Participants

Reaction Steps

The process is performed as in Example 75, starting with 500 mg of 2-chloro-N-(6-chloro-1H-indazol-3-yl)acetamide, 15 cm3 of acetonitrile and 0.61 cm3 of piperidine. The reaction medium is refluxed for 2 hours, the precipitate formed is then filtered off on a sinter funnel and the crystals, after taking up in methanol, are purified by chromatography under an argon pressure of 50 kPa, on a column of silica gel (particle size 40-60 μm; diameter 2.5 cm), eluting with a methylene chloride/methanol mixture (93/7 by volume). The fractions containing the expected product are combined and evaporated under reduced pressure (2 kPa; 50° C.); the residue is taken up in 5 cm3 of diethyl ether, filtered off and dried (90 Pa; 45° C.) to give 447 mg of N-(6-chloro-1H-indazol-3-yl)-1-piperidineacetamide in the form of a white powder melting at 153° C.

Provenance & Evidence