反应详情

To a suspension of O-tert-butyl N-(piperidin-4-yl)carbamate (4.0 g) in dichloromethane (40 ml) were added pyridine (1.94 ml), dichloromethane (40 ml), acetic anhydride (20.8 ml) and then N,N-dimethylaminopyridine (0.1 g) at ambient temperature. After stirring for 3 hours, the mixture was washed with 0.1N hydrochloric acid, water, and brine. After drying with magnesium sulfate, the solvents were removed under reduced pressure. After rinse with diisopropyl ether, O-tert-butyl N-(1-acetylpiperidin-4-yl)carbamate (4.01 g) was obtained.

1. customat ambient temperature
2. washthe mixture was washed with 0.1N hydrochloric acid, water, and brine
3. dry with materialAfter drying with magnesium sulfate
4. customthe solvents were removed under reduced pressure
5. washAfter rinse with diisopropyl ether