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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 497857Generated: October 31, 2026

Methanol → HCID 22318959, compound

https://huagongshe.com/reaction/497857

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantHCID 22318940HCID 22318940—
CatalystHCID 178418390HCID 178418390—
SolventHCID 178418361HCID 178418361—
ProductHCID 22318959HCID 2231895962.3%

Reaction Steps

52 mg of 1-[3-(benzyloxy)phenyl]-3-(2-cyanophenyl)-5-(2-pyridyl)-1,2-dihydropyridin-2-one and 20 mg of 5% palladium-carbon were added to 3 ml of methanol, followed by stirring at room temperature in hydrogen atmosphere overnight. After the resulting insoluble matters were filtered off, the filtrate was evaporated. The residue was purified by silica gel chromatography (ethyl acetate/hexane system), to give 26 mg the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06949571B2
Source datasetuspto-grants-2005_09
ORD IDord-d53e70a00d32435c91f51b96c9d84e0c
Source noteuspto-grants-2005_09