反应详情

Sodium thiomethoxide (2.02 g of 95%, 27.40 mmol) was added in a single portion to a solution of 1-(4-chlorobutyl)-2-methyl-1H-imidazo[4,5-c]quinoline (5.0 g, 18.26 mmol) in anhydrous N,N-dimethylformamide (91 mL). After 30 minutes the reaction mixture was poured with rapid stirring into water (500 mL). The resulting solution was extracted with chloroform (2×200 mL). The organic layers were combined, washed with saturated aqueous sodium bicarbonate (100 mL) then with brine (100 mL), dried over sodium sulfate, filtered and then concentrated under reduced pressure to provide 5.0 g 2-methyl-1-[4-(methylthio)butyl]-1H-imidazo[4,5-c]quinoline as a light yellow oil.

1. additionAfter 30 minutes the reaction mixture was poured
2. extractionThe resulting solution was extracted with chloroform (2×200 mL)
3. washwashed with saturated aqueous sodium bicarbonate (100 mL)
4. dry with materialwith brine (100 mL), dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure