2-Hydrazinopyridine → 2-[[3-Methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

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Reaction Steps

A solution of 2-(2-oxopropyl)-4H-3,1-benzoxazin-4-one (68.2 g, 0.34 mol) and 2-hydrazinopyridine (37.1 g, 0.34 mol) in ethanol (500 mL) was heated under reflux for 1 hour. After the solution was cooled to room temperature, the resulting crystals were collected by filtration. The crystals were washed with ethanol and air dried to give the title compound (50.2 g, 51% yield).

Provenance & Evidence