反应详情

A solution of 2-(2-oxopropyl)-4H-3,1-benzoxazin-4-one (16.7 g, 82.4 mmol), 4-hydrazinopyridine hydrochloride (12.0 g, 82.4 mmol) and sodium acetate (8.10 g, 98.9 mmol) in ethanol (300 mL) was heated under reflux for 30 minutes. The solution was cooled to room temperature and concentrated under reduced pressure. The residue was poured into water and the resulting crude crystals were collected by filtration. The crystals were washed with ethanol and air dried to give the title compound (11.9 g, 49% yield).

1. temperatureunder reflux for 30 minutes
2. concentrationconcentrated under reduced pressure
3. additionThe residue was poured into water
4. filtrationthe resulting crude crystals were collected by filtration
5. washThe crystals were washed with ethanol and air
6. customdried