2-Hydrazinopyridine → ethyl 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate

Participants

Reaction Steps

A solution of ethyl 2-(ethoxymethylene)-2-cyanoacetate (33.8 g, 200 mmol) and 2-hydrazinopyridine (21.8 g, 200 mmol) in ethanol (100 mL) was heated under reflux for 20 minutes. The solution was cooled to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol and air dried to give the title compound (33.8 g, 73% yield).

Provenance & Evidence