Water → HCID 22320218, compound

Participants

Reaction Steps

A solution of 1-(2-pyridinyl)-1H-pyrazol-5-ylamine (6.02 g, 37.6 mmol), 2-iodobenzoic acid (9.32 g, 37.6 mmol), copper acetate (II) (0.683 g, 3.76 mmol) and potassium carbonate (5.72 g, 41.4 mmol) in N,N-dimethylformamide (20 mL) was heated under reflux for 1 hour under an argon atmosphere. The solution was allowed to cool to room temperature, and poured into water. The solution was made weakly acidic by the addition of acetic acid, and the resulting crude crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (9.45 g, 90% yield).

Provenance & Evidence