Hydrogen chloride-ethyl acetate → HCID 22320399, compound

HRID 498008Notes

Reaction equation

HRID 498008 reaction equation
[CH3:1][C:2]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([C:13]=2[NH2:15])=[CH:11][CH:10]=[CH:9][CH:8]=3)[N:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[N:3]=1.[ClH:22].C(OCC)(=O)C>C(O)C>[ClH:22].[CH3:1][C:2]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([C:13]=2[NH2:15])=[CH:11][CH:10]=[CH:9][CH:8]=3)[N:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[N:3]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22320213HCID 22320213, compound

Product 1

HCID 22320399HCID 22320399, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinolin-4-ylamine (1.56 g, 5.65 mmol) in ethanol (5 mL), a solution of 4N hydrochloric acid/ethyl acetate (10 mL) was added, and the solution was concentrated under reduced pressure. The residue thus obtained was recrystallized from ethanol to give the title compound (1.41 g, 80% yield).

Workup

  1. concentrationthe solution was concentrated under reduced pressure
  2. customThe residue thus obtained
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-e843deb1995b4187bfc4ee33a51eb42c
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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