Thiophenol → 5-Bromo-2-chloro-4-(phenylthio)pyrimidine

HRID 49801Notes

Reaction equation

HRID 49801 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[C:10]1([SH:16])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Br:1][C:2]1[C:3]([S:16][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 7969ThiophenolHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 790726395-Bromo-2-chloro-4-(phenylthio)pyrimidine

Procedure

Using an analogous method to that described in Method 1, but starting from 5-bromo-2,4-dichloropyrimidine and thiophenol, the product was obtained. NMR: 7.6 (m, 5H), 8.8 (s, 1H).

Workup

  1. customthe product was obtained

Sources & evidence

ORD record
ord-99b646fbcedb4fa08746bae593920360
Source dataset
uspto-grants-2004_03
Patent number
US06710052B2

Reaction notes

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