HCID 135482311, compound → HCID 135848083, compound

HRID 498036Notes

Reaction equation

HRID 498036 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[NH:8][C:7]1[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:6]=1[C:5]2=[O:23]>C(O)C.O>[OH2:23].[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[NH:8][C:7]1[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:6]=1[C:5]2=[O:23]

Participants

4

Reactant 1

HCID 135482311HCID 135482311, compound

Product 1

HCID 135848083HCID 135848083, compoundYield 196.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A suspension of 6,7-difluoro-3-methyl-1-(2-pyridinyl)-1,9-dihydro-4H-pyrazolo[3,4-b]quinolin-4-one (20.00 g, 64 mmol) in ethanol (200 mL) and water (200 mL) was heated under reflux for 6 hours. The suspension was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with water and air dried to give the title compound (20.77 g, 98% yield).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 6 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with water and air
  5. customdried

Sources & evidence

ORD record
ord-0483c59ae8f44dd3bf7624ee47e32cff
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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