反应详情

温度

105 °C

In a three-necked flask with a capacity of 3 liters, 253.11 g of methyl 5-bromo-3-(hydroxymethyl)benzoate were placed and mixed with 2000 ml of toluene, and the resultant mixture was agitated to prepare a solution. The resultant solution was mixed with 44 g of manganese dioxide, and the resultant reaction mixture liquid was heated to a temperature of 105° C. and agitated for 7 hours. The resultant reaction mixture liquid was allowed to be cooled to room temperature and filtered to remove a solid fraction therefrom, and the resultant filtrate was concentrated. The target compound, methyl 5-bromo-3-formylbenzoate was obtained in an amount of 236.79 g which corresponded to a yield of 94.3%.

1. customto prepare a solution
2. customthe resultant reaction mixture liquid
3. customThe resultant reaction mixture liquid
4. temperatureto be cooled to room temperature
5. filtrationfiltered
6. customto remove a solid fraction
7. concentrationthe resultant filtrate was concentrated