Ethylene Glycol → 2-(4-Tert-butylphenyl)-2-(3-chloropropyl)-1,3-dioxolane

Participants

Reaction Steps

This compound was synthesized as described under 5.a) with 20.0 g (83.8 mmol) of 1-(4-tert-butylphenyl)-4-chloro-1-butanone (origin: Acros), 16 ml of ethylene glycol and ca. 1 g of p-toluenesulfonic acid in 120 ml of toluene for 16 h to give 24.1 g (99%) of the crude compound, which was used for further functionalization. Column chromatography of 3 g (SiO2, heptane/ether 4:1) afforded 2.48 g of a slightly yellow oil.

Provenance & Evidence