HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 49816Generated: October 25, 2026
Water → 4-Acetyl-n-(3-(1-acetylpiperazin-4-yl)phenyl)-2-nitroaniline
https://huagongshe.com/reaction/49816
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4'-Fluoro-3'-nitroacetophenone | HCID 2734612 | — |
| Reactant | 1-[4-(3-Aminophenyl)piperazin-1-yl]ethan-1-one | HCID 11117539 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-Acetyl-n-(3-(1-acetylpiperazin-4-yl)phenyl)-2-nitroaniline | HCID 22330226 | — |
Reaction Steps
A mixture of 1b (0.75 g, 4.1 mmol) and 2d (0.9 g, 4.1 mmol) in anhydrous NMP (2 ml) was heated to 80° C. overnight under a stream of nitrogen. After cooling water (20 ml) was added and the mixture was extracted with dichloromethane. The organic extract was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was purified by column-chromatography on silica gel using ethyl acetate as the eluent to yield 4-acetyl-N-(3-(1-acetylpiperazin-4-yl)phenyl)-2-nitroaniline as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06710044B2 |
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| Source dataset | uspto-grants-2004_03 |
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| ORD ID | ord-da6a3f7e113d4c7caef77cfec8bc0628 |
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| Source note | uspto-grants-2004_03 |
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