HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → tert-Butyl (4-chloro-2-nitrophenyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | 4-Chloro-2-nitroaniline | HCID 6979 | — |
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | Isocyanate | HCID 105034 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-Butyl (4-chloro-2-nitrophenyl)carbamate | HCID 53980145 | — |
Reaction Steps
The title compound was prepared via the isocyanate from commercially available 4-chloro-2-nitro-phenylamine [CAS-No. 89-63-4] (5.0 g, 29 mmol) with diphosgene (1.75 mL, 14.5 mmol) in EtOAc (60 mL), followed by treatment with tert-BuOH (30 mL) in CH2Cl2 (60 mL) according to the general procedure A (method a). Obtained as a yellow solid (6.2 g, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-4f06c740e5634043a74bf44a87746c3f |
| Source note | uspto-grants-2005_09 |