Dimethylamine → (2-Dimethylamino-2'-fluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert-butyl ester

HRID 498175Notes

Reaction equation

HRID 498175 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[C:10](Cl)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[NH:26]([CH3:28])[CH3:27]>CS(C)=O>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[C:10]([N:26]([CH3:28])[CH3:27])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 69486785HCID 69486785, compound

Product 1

HCID 69489429(2-Dimethylamino-2'-fluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert-butyl ester

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from (2-chloro-2′-fluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert-butyl ester (Example D1) (9.568 g, ca. 26 mmol) and Me2NH (60% in H2O, 12 mL) in DMSO (87 mL) at 23° C. according to the general procedure C. Obtained as a yellow solid (4.54 g).

Sources & evidence

ORD record
ord-1710695581b54ce6b9c09f4b7500f96e
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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