(2-Nitro-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl ester → (2-Amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl ester

HRID 498198Notes

Reaction equation

HRID 498198 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[CH:15]2)=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:15]=[CH:16][CH:17]=[CH:18]2)=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69487086(2-Nitro-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 69488996(2-Amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl ester

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from (2-nitro-4-pyrrol-1-yl-phenyl)-carbamic acid tert-butyl ester (Example A11) by hydrogenation with 5% Pd/C according to the general procedure J (method a). Obtained as a white solid (9.06 g).

Sources & evidence

ORD record
ord-b131bdfd778344a88e8cb7cbb4fe434a
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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