(2-Nitro-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester → Carbamic acid,[2-amino-4-(trifluoromethoxy)phenyl]-,1,1-dimethylethyl ester

HRID 498213노트

반응식

HRID 498213 반응식
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 1

HCID 69489589(2-Nitro-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester

생성물 1

HCID 69489489Carbamic acid,[2-amino-4-(trifluoromethoxy)phenyl]-,1,1-dimethylethyl ester

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

The title compound was prepared from (2-nitro-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester (Example A22) (10.38 g, 32.2 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a light brown solid (8.76 g, 93%).

출처 및 근거

ORD 기록
ord-2fac2924806b4032976ad77bf9f8f930
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949542B2

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