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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 498219Generated: October 26, 2026

[5-(2-Methoxy-ethoxy)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester → Carbamic acid,[2-amino-5-(2-methoxyethoxy)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

https://huagongshe.com/reaction/498219

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[5-(2-Methoxy-ethoxy)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl esterHCID 69489799—
CatalystPalladiumHCID 23938—
ProductCarbamic acid,[2-amino-5-(2-methoxyethoxy)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl esterHCID 69487070—

Reaction Steps

The title compound was prepared from [5-(2-methoxy-ethoxy)-2-nitro-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example A26) (7.90 g, 20.8 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a yellow solid (7.00 g, 96%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06949542B2
Source datasetuspto-grants-2005_09
ORD IDord-aa136c95a95c448280d5e98662a32658
Source noteuspto-grants-2005_09