HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → (2-Amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | (5-Cyclopropyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 69489771 | — |
| Product | (2-Amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 69489287 | — |
Reaction Steps
The title compound was prepared from (5-cyclopropyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example A31) (460 mg, 1.33 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as an orange solid (300 mg, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-6f43cdd9ae8442aaa45d53dad143e643 |
| Source note | uspto-grants-2005_09 |