反应详情

温度

0 °C

A suspension of 4-fluorophenylacetic acid (10.0 g, 64.9 mmol) in concentrated sulfuric acid (100 ml) was cooled to 0° C. Concentrated nitric acid (4.5 ml, 65 mmol) was added drop-wise, keeping the temperature at 0-5° C. At the end of the addition the mixture was poured into ice-water (400 ml). The precipitate was filtered off, washed thoroughly with water and dried with suction to yield 1i (9.11 g, 70%).

1. customat 0-5° C
2. additionAt the end of the addition the mixture
3. filtrationThe precipitate was filtered off
4. washwashed thoroughly with water
5. customdried with suction