HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 3-(2-Acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | 3-(2-Methyl-pyridin-4-yl)-benzoic acid methyl ester | HCID 69489145 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | 3-(2-Acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester | HCID 69486601 | 161.2% |
Reaction Steps
Oxidation of 3-(2-methyl-pyridin-4-yl)-benzoic acid methyl ester (26.2 g, 0.11 mol; example K12) with H2O2 (30%, 31.5 ml, 0.31 mol) in acetic acid (117 ml) at 70° C. for 27 h and subsequent reaction of the N-oxide in acetic acid anhydride (22 ml) at 135° C. for 30 min yielded after aqueous work-up 3-(2-acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester (25.3 g, 82%) as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-8d92bc8c26f649549c6afb186889ca2c |
| Source note | uspto-grants-2005_09 |