tert-Butyl acetate → (RS)-3-{3-[2-Methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propionic acid tert-butyl ester
Reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[C:14]([CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[N:13]=[C:12]([CH3:24])[CH:11]=2)[CH:5]=1.[C:26]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])(=[O:28])[CH3:27]>>[C:30]([O:29][C:26](=[O:28])[CH2:27][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[C:14]([CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[N:13]=[C:12]([CH3:24])[CH:11]=2)[CH:5]=1)=[O:2])([CH3:33])([CH3:32])[CH3:31]Participants
3
Procedure
Reaction of (RS)-3-[2-methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-benzoic acid methyl ester with tert.-butyl acetate according to general procedure K (method d; example K8) yielded the title compound as a yellow oil.
Sources & evidence
- ORD record
- ord-47005ef636f4491ba2697a7575e3415a
- Source dataset
- uspto-grants-2005_09
- Patent number
- US06949542B2
Reaction notes
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