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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 498257Erstellt: 25. Oktober 2026

Carbamic acid,n-[2-amino-5-(dimethylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester → {5-Dimethylamino-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/498257

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktCarbamic acid,n-[2-amino-5-(dimethylamino)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl esterHCID 67362752—
Edukt3-Oxo-3-(3-pyridin-2-yl-phenyl)-propionic acid tert-butyl esterHCID 69489201—
Produkt{5-Dimethylamino-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl esterHCID 86589222—

Reaktionsschritte

The title compound was prepared from (2-amino-5-dimethylamino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J1) (239 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic acid tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a pink solid (295 mg).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06949542B2
Quelldatensatzuspto-grants-2005_09
ORD IDord-18eec6bf5896412198a525d6871e8dc7
Quellennotizuspto-grants-2005_09